Klean Prep: Discontinuation

Klean Prep is being discontinued globally (Pharmacode 790753). We are listing a replacement Plenvu (Pharmacode 2569671) on 1 May 2023.

Affected product

Norgine (the supplier) is discontinuing Klean Prep (macrogol 3350 + potassium chloride, sodium chloride, sodium sulfate) – Pharmacode: 790753. This is a global issue. 

We anticipate supplies of Klean Prep will run out during August 2023. Klean Prep will remain listed until 1 April 2024 to allow time for all stock to be used and claimed for.

Hospital Medicine List (HML) listing for Klean Prep(external link)

This does not affect other bowel-cleansing preparations listed in the HML(external link)

Note: Klean Prep is only listed on the HML.

Alternative product

We are listing Plenvu (Pharmacode: 2569671) from 1 May 2023 as an alternative. We secured Plenvu through our annual tender process. This listing provides continuity of supply for people where the other funded options may not be suitable.

HML listing for Plenvu(external link)

Full decision details for the Plenvu listing

Key dates

1 May 2023 – Plenvu listed on the Pharmaceutical Schedule. 

August 2023 – Stock of Klean Prep is expected to run out.

1 April 2024 – Klean Prep will be delisted from the Pharmaceutical Schedule.

Key differences between Klean Prep and Plenvu

There are some differences between Klean Prep and Plenvu. These are summarised in the table below. Full details about Plenvu and Klean Prep are available from the Medsafe datasheet.

Product name 

Plenvu

Klean Prep

Ingredients

Macrogol 3350 + sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate and ascorbic acid

Macrogol 3350 with potassium chloride, sodium bicarbonate, sodium chloride, and sodium sulfate

Medsafe Datasheet

Plenvu Datasheet(external link)

Klean-Prep Datasheet(external link)

Form

Powder for oral solution, 3 sachets

Powder for oral solution, 4 sachets

Active ingredients details

Dose 1 sachet:

  • macrogol 3350 100 g
  • potassium chloride 1 g
  • sodium chloride 2 g
  • sodium sulfate 9 g

Dose 2 (sachet A and B)

Sachet 2A:

  • macrogol 3350 40 g
  • potassium chloride 1.2 g
  • sodium chloride 3.2 g

Sachet 2B:

  • ascorbic acid 7.54 g
  • sodium ascorbate 48.11 g

4x sachets each containing:

  • macrogol 3350 59 g
  • potassium chloride 0.7425 g
  • sodium bicarbonate 1.685 g
  • sodium chloride 1.465 g
  • sodium sulfate 5.685 g

Preparation instructions

The first dose is supplied in sachet 1.

Dose 2 is supplied in two sachets, sachet A and sachet B.

Each dose is made up by dissolving the sachet(s) with 500 mL of water. 

An additional 500 mL of clear fluid must be taken with each dose. 

Each 500 mL dose and 500 mL additional clear fluids should be taken over 60 minutes.

Each sachet is dissolved in 1 L of water. 

Usual dose is 4 sachets taken at a rate of 250 mL every 10 to 15 minutes.

Recommended dosing regimen

  • Two-day split dosing schedule with the first 500 mL dose of PLENVU (including additional 500 mL of clear fluid) taken in the evening before the clinical procedure and the second 500 mL dose (including an additional 500 mL of clear fluid) in the morning of the day of the clinical procedure (approximately 12 hours after the start of the first dose)
  • Morning only dosing schedule with both doses taken in the morning of the day of the clinical procedure (including an additional 500 mL of clear fluid); the second dose should be taken a minimum of 2 hours after the start of the first dose
  • Day before dosing schedule with both doses taken in the evening before the clinical procedure (including an additional 500 mL of clear fluid); the second dose should be taken a minimum of 2 hours after the start of the first dose.
  • All four sachets should be taken within 4-6 hours, or
  • Administration may be divided, for example, taking 2 sachets during the evening before the examination, and the remaining 2 sachets on the morning of the examination.

Flavour

Mango and fruit punch

Vanilla

Excipients

Citric acid, mango flavour VA93382, sucralose, aspartame, fruit mix flavour (fruit punch) FV654 VA93402

Aspartame, vanilla

Reconstituted shelf life

24 hours reconstituted stored at or below 25oC (or in a refrigerator).

24 hours reconstituted stored in the refrigerator (2-8 degrees).

Who to contact

If you have any queries regarding the funding of bowel cleansing preparations, email enquiry@pharmac.govt.nz

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