Imipramine (Tofranil) tablets 25 mg: Supply issue resolved

AFT Pharmaceuticals (the supplier) have advised PHARMAC that imipramine hydrochloride (Tofranil) 25 mg tablets are back in stock. 

On this page

Update: 18 August 2021

The supply issue is resolved. Supplies of Tofranil 25 mg imipramine tablets being distributed. 

About the medicine

Imipramine is an antidepressant medicine used for depression and other serious mental health conditions. About 500 patients in New Zealand are using imipramine hydrochloride 25 mg tablets.

Tofranil is the only brand of imipramine hydrochloride tablets currently approved by Medsafe. The supplier, AFT Pharmaceuticals, has been unable to source an alternative brand that is chemically equivalent.  

There is no shortage of the 10 mg strength of imipramine tablets. 

Information for people taking imipramine (Tofranil) 25 mg

If you are taking the 25 mg tablet of imipramine, you will need to contact your prescriber about alternatives. 

There is no shortage of imipramine hydrochloride 10 mg tablets. If you are only using imipramine hydrochloride 10 mg tablets, you do not need to contact your prescriber.   

We know that changes to your medicine can be disruptive. We’re working hard to keep this to a minimum. Thank you for your understanding.

Information for prescribers

Prescribers will need to:

  • ensure no new patients are started on imipramine hydrochloride 25 mg and
  • either transition patients currently on imipramine hydrochloride 25 mg to an alternative treatment while imipramine hydrochloride 25 mg is out of stock
  • or consider using an appropriate number of imipramine hydrochloride 10 mg tablets (including alternate day different dosing) to maintain therapeutic benefits for your patient. 

We have received advice from our Mental Health Subcommittee that using multiple 10 mg tablets to maintain the correct dose could be a temporary alternative.

The supplier, AFT, has informed PHARMAC that they have adequate supply of imipramine hydrochloride 10 mg tablets to manage an increase in demand if it were used by all patients who usually use the 25 mg during the out of stock situation. 

Alternative funded medicines

If decide to change medication, please note that there are stock issues for some other antidepressants

Check the Schedule for all funded medicines available for depression and anxiety(external link) 

Further advice

BPACnz has published information on the role of medicines in the management of depression in primary care which may be useful.

Read The Role of Medicines in the Management of Depression in Primary Care – BPACnz(external link)

Information for pharmacists

You will need to tell people using imipramine hydrochloride 25 mg tablets to contact their prescriber to get advice about an appropriate alternative treatment to use during the out of stock.  

We are working closely with the supplier to ascertain a resupply date.

Thank you for the work you do supporting your patients during stock issues and other changes.

Who to contact

If you are a prescriber or pharmacist with questions about this short supply issue:

If you take imipramine hydrochloride (Tofranil) 25 mg tablets, contact your doctor, nurse, or pharmacist. PHARMAC cannot give clinical advice to individuals.

If you need to talk:

  • call or text 1737 any time (it’s free)
  • talk to a trained counsellor on the Depression helpline, 0800 111 757