NPPA outcome data

Summary of application results for 2019

Outcome Number of applications
Approved 356
Declined  2
Principles not met 430
Withdrawn application 101
Grand Total 889

Download the data as a spreadsheet (includes medicines, outcomes and some indications)

Note: We have excluded information about some applications for privacy reasons. Call the team if you have any questions about your particular medicine.

Outcomes of applications by medicine 2019

There is a breakdown by indication for each of the medicines in bold in the Excel spreadsheet download.  

Medicine Approved Declined Principles not met Withdrawn application Grand Total
4 aminopyridine 1       1
40% glucose gel (Glucogel) 1       1
abiraterone 1       1
adalimumab 2   6   8
aflibercept     2 1 3
albendazole 1     1 2
alectinib     1   1
alpha tocopheryl acetate 5     2 7
alteplase 1       1
amikacin 1       1
amiloride 3   3 4 10
amphotericin b       1 1
anakinra 5   2 3 10
apixaban     2   2
aprepitant 1   1   2
aripiprazole     5   5
asparaginase (Crisantaspase) 3       3
atomoxetine 1       1
atp support (Bioceuticals) 1       1
axitinib     1   1
azacitidine 6   2 1 9
bacillus calmette-guerin vaccine       1 1
basiliximab       1 1
bedaquiline 9     1 10
belinostat 1       1
bendamustine     1   1
bevacizumab 6   1   7
bortezomib 6       6
botulinum toxin type b 2       2
brentuximab 1   3   4
brimonidine (Alphagan P) 1   2   3
budesonide     2   2
buprenorphine       1 1
calcitonin       1 1
candesartan     1   1
cannabidiol     1   1
cannabidiol (Sativex)     1   1
cannabidiol (Tilray)     8   8
capsaicin     1   1
captopril     1   1
carbidopa / levodopa (Sinemet)       1 1
ceftolozane-tazobactam 2       2
cefuroxime     1   1
chlorhexidine     1 1 2
chlorvescent       1 1
cholestyramine 2       2
cimetidine     1   1
cinacalcet     8   8
cincalcet     1   1
citalopram     1   1
coenzyme q10 3       3
colesevelam 1   3   4
collagenase clostridium histolyticum     1   1
continuous glucose monitor 2   11   13
creatine 1       1
cyclosporin 26       26
dabrafenib 2   3   5
daratumumab     71 1 72
deferasirox 3   1   4
deferiprone 2   1   3
deflazacort     1   1
delamanid 1       1
demeclocycline 1   1 1 3
denosumab 2   3   5
desvenlafaxine     1   1
dexamethasone     5   5
dexrazoxane     1   1
dienogest       1 1
diethylcarbamazine 1       1
diloxanide     1   1
dipyridamole 3       3
dornase alfa 2       2
droxidopa     1   1
duloxetine     3 1 4
dupilumab     2   2
dutasteride     1   1
eculizumab       1 1
elecare powder       1 1
eltrombopag 3   4 3 10
enoxaparin 6   3 2 11
enzalutamide     1   1
eplerenone     1   1
erenumab     1   1
erlotinib 3       3
escitalopram (Airflow)     1   1
escitalopram (Lexapro)     1   1
escitalopram (Mylan)     1   1
estradiol     1   1
etanercept 4   1   5
everolimus 1   1 4 6
evolocumab 1       1
exenatide     1   1
ezetimibe       1 1
famotidine       4 4
felbamate 1       1
ferric carboxymaltose     2   2
filgrastim     1   1
flash glucose monitoring system     6   6
flucytosine     1   1
folinic acid       1 1
fondaparinux       1 1
food thickener     3   3
formula (Energivit) 1       1
formula (Locasol) 2       2
formula (Neocate junior)     1   1
fortijuice     1   1
fortisip     2 1 3
fosaprepitant 1       1
fosfomycin       1 1
gabapentin (Neurontin)     1   1
gabapentin (Nupentin)     1   1
ganciclovir 2       2
gemcitabine       1 1
gentamicin     1   1
gilteritinib       1 1
glycine 1       1
glycopyrrolate 1       1
glycosade 1       1
guanfacine     1   1
hexamine hippurate     1   1
human papillomavirus vaccine     1   1
hydroxocobalamin 2       2
ibrutinib   1 6 1 8
idebenone 1       1
indomethacin 6   2   8
infliximab     5 3 8
insulin detemir     2 1 3
ipilimumab   1 1   2
isonizid 1       1
itraconazole       1 1
ivabradine     5   5
ivacaftor     1   1
ketamine 7     1 8
ketoconazole 1       1
ketotifen 1       1
lanreotide     1   1
l-arginine 3       3
larotrectinib     1   1
latanoprost     1   1
l-carnitine 3       3
lenalidomide 3   3 2 8
leuprorelin       1 1
levofloxacin 3   2 1 6
levonorgestrel     4 3 7
lidocaine with prilocaine     2   2
linezolid 9     4 13
liothyronine     1   1
liposomal doxorubicin     2 1 3
lisdexamfetamine     1   1
l-taurine 5       5
l-tyrosine 1       1
melatonin     2   2
memantine     1   1
mepolizumab     5   5
methotrexate (Methoblastin)     1   1
methyl prednisolone     1   1
methylphenidate     2   2
migalastat     2   2
mirabegron     5   5
mitotane 2       2
moxifloxacin 3   1 1 5
multivitamin      1 2 3
mycophenolic acid      1   1
nab paclitaxel     1   1
naltrexone     2   2
nimodipine       1 1
nitazoxanide       1 1
nivolumab     1   1
nusinersen     1   1
ocrelizumab     2   2
octreotide 1   2   3
omalizumab     1   1
omeprazole      1   1
ondansetron 1       1
oseltamivir       1 1
osimertinib     1   1
oxandrolone       1 1
oxcarbazepine     1   1
palbociclib     1   1
palivizumab     4   4
paracetamol with codeine      1   1
paromomycin       1 1
pazopanib     2   2
peginterferon alpha-2a 1   3   4
pegvisomant 1       1
pegylated liposomal doxorubicin     2   2
pembrolizumab     4   4
pemetrexed     1   1
perampanel     1   1
pertuzumab     1   1
phentermine     1   1
picosalax     1   1
pimecrolimus       1 1
pipobroman 2       2
plasmalyte  1       1
plerixafor 1       1
pneumococcal (pcv13) polysaccharide conjugate vaccine  1   2   3
polidocanol        1 1
ponatinib     1 1 2
posaconazole 5   1 1 7
potassium chloride  1   1   2
potassium citrate     2   2
prasugrel 2   1   3
prednisilone       1 1
pristinamycin 14       14
propranolol 1       1
pyrimethamine 1       1
quinagolide 2       2
quinidine 1       1
raltitrexed     1   1
reboxetine     1   1
recombinant follicle stimulating hormone     1   1
regorafenib     1   1
ribavirin       1 1
riboflavin 3   1   4
risperidone     1   1
rituximab 38   26 8 72
rosuvastatin     4   4
rufinamide 4       4
ruxolitinib 8   2   10
sapropterin 1       1
sargramostim 1       1
secukinumab 1   5   6
sertraline     1   1
sevelamer     1   1
simethicone     1   1
sirolimus ointment 7       7
sirolimus oral 16   1   17
sitafloxacin 1       1
sodium benzoate 1       1
sodium chloride (eye drops)     1   1
sodium chloride (Slow Sodium)     6   6
sodium dl 3-hydroxybutyrate 3       3
sodium picosulfate (Picoprep) 1       1
sodium picosulfate, magnesium oxide, citric acid (Picosalax) 1       1
sofosbuvir/valpatasvir     1 1 2
solifenacin succinate (Vesicare)     1   1
somatropin 1       1
sorafenib 1       1
spiramycin       1 1
stanozolol 1       1
sunitinib     3   3
tacrolimus (Prograf XL) 1   1   2
tacrolimus ointment 2   1   3
tafamidis     4   4
tamoxifen     1   1
taurolidine and citrate solution (Taurolock) 1       1
temozolomide     1   1
teniposide 1       1
tenofovir alafenamide 1   1   2
teriparatide     3   3
thalidomide 2   1   3
tibolone     2   2
ticagrelor 1       1
tinidazole 1       1
tizanidine     2   2
tobramycin       1 1
tocilizumab 8   4 1 13
tofacitinib     5   5
trametinib     2   2
tranexamic acid     1   1
trastuzumab     3   3
trazodone     1   1
treosulphan 3       3
trihexyphenidyl     3   3
ustekinumab     4   4
valganciclovir 8     1 9
varicella vaccine (Varilrix)     1   1
vedoluzimab     1   1
venetoclax     1   1
venlafaxine 1   6 6 13
vismodegib     3   3
voriconazole 4       4
whole thyroid     1   1
zinc 2       2
zoledronic acid (Aclasta)     2   2
zonisamide 3     2 5
Grand Total 356 2 430 101 889