NPPA outcome data
The data on this page relates to applications received in the 2021/2022 financial year.
Updated data
The table below gives the number of applications and the result of the application by chemical. The Excel spreadsheet download provides indications (by chemical), where providing this information will not impact anyone's privacy.
This detail is also available in a searchable web page(external link)
Previous data
- NPPA Data 2021 22 Includes indications [XLSX 29 KB]
| Chemical | Approved | Declined | Principles not met | Withdrawn | Grand Total |
|---|---|---|---|---|---|
| acetic acid | 1 | 1 | |||
| acetylcysteine | 1 | 1 | 2 | ||
| adalimumab | 3 | 2 | 3 | 8 | |
| adalimumab (Amgevita) | 1 | 1 | |||
| aflibercept | 1 | 1 | |||
| alectinib | 1 | 1 | 2 | ||
| alglucosidase alfa | 2 | 2 | |||
| alirocumab | 1 | 1 | 2 | ||
| alitretinoin | 3 | 3 | |||
| alpha tocopheryl acetate | 2 | 2 | |||
| alpha tocopheryl acetate (Micelle E) | 1 | 1 | |||
| amantadine hydrochloride | 1 | 1 | |||
| ambrisentan | 1 | 1 | |||
| amifampridine [3,4-diaminopyridine] | 2 | 2 | |||
| amikacin | 1 | 1 | |||
| amiloride hydrochloride | 1 | 1 | |||
| amino acid formula (without isoleucine, leucine and valine) | 6 | 0 | 0 | 0 | 6 |
| amino acid formula (without methionine) (hcu lophlex lq20) | 1 | 1 | |||
| amino acid formula low calcium (Locasol) | 4 | 4 | |||
| anakinra | 5 | 1 | 1 | 7 | |
| apixaban | 1 | 1 | |||
| aprepitant | 3 | 1 | 1 | 5 | |
| arginine (Vitaflo Arginine2000) | 1 | 1 | |||
| aripiprazole | 2 | 2 | |||
| asfotase alpha | 1 | 1 | |||
| asparaginase (Erwinase) | 1 | 1 | |||
| atezolizumab | 6 | 6 | |||
| atovaquone | 1 | 1 | |||
| azacitidine | 9 | 1 | 1 | 11 | |
| azithromycin | 2 | 1 | 3 | ||
| bedaquiline | 8 | 1 | 9 | ||
| belimumab | 3 | 3 | |||
| bendamustine hydrochloride | 1 | 1 | 2 | ||
| bevacizumab | 2 | 1 | 1 | 4 | |
| bilastine | 1 | 1 | |||
| bimatoprost preservative free | 1 | 1 | |||
| biotin | 1 | 1 | |||
| blinatumomab | 3 | 3 | |||
| bortezomib | 2 | 2 | |||
| bosutinib | 1 | 1 | |||
| brentuximab vedotin | 2 | 3 | 5 | ||
| bromocriptine | 1 | 1 | |||
| bromocriptine mesylate | 1 | 1 | |||
| budesonide | 2 | 2 | 4 | ||
| buprenorphine | 1 | 1 | |||
| burosumab | 2 | 2 | |||
| cannabinoid | 1 | 0 | 7 | 1 | 9 |
| cefiderocol | 2 | 2 | |||
| ceftazidime and avibactam | 1 | 1 | |||
| ceftolozane/tazobactam | 1 | 1 | |||
| chloramphenicol | 1 | 1 | |||
| ciclosporin eye preparations | 56 | 1 | 1 | 58 | |
| cinacalcet | 2 | 5 | 7 | ||
| citrulline | 1 | 1 | |||
| clofarabine | 1 | 1 | |||
| cobimetinib | 1 | 1 | |||
| coenzyme q10 | 1 | 1 | |||
| colesevelam | 1 | 1 | |||
| colistin sulphomethate | 1 | 1 | |||
| continuous glucose monitoring system (Dexcom glucose transmitters and sensors) | 2 | 1 | 3 | ||
| continuous glucose monitoring system (Dexcom g6 alarmed interstitial glucose sensor) | 1 | 1 | |||
| continuous glucose monitoring system (Dexcom G6 sensors) | 1 | 1 | |||
| continuous glucose monitoring system (Dexcom G6 transmitter) | 1 | 1 | |||
| continuous glucose monitoring system (Dexcom) | 2 | 2 | |||
| continuous glucose monitoring system (Freestyle Libre) | 1 | 1 | |||
| continuous glucose monitoring system (FreeStyle Libre: Flash Glucose Monitoring System) | 1 | 1 | |||
| continuous glucose monitoring system (Guardian Connect transmitter) | 1 | 1 | |||
| continuous glucose monitoring system (Guardian Sensor 3) | 1 | 1 | |||
| cyanocobalamin (Vitamin B12) | 1 | 1 | |||
| cyclopentolate eye preperations | 1 | 1 | |||
| dabrafenib | 3 | 3 | |||
| danazol | 4 | 4 | |||
| daratumumab | 1 | 1 | |||
| deferasirox | 1 | 2 | 3 | ||
| deferiprone | 2 | 2 | |||
| degarelix | 1 | 1 | |||
| demeclocycline hydrochloride | 1 | 1 | 2 | ||
| denosumab | 5 | 4 | 1 | 10 | |
| desogestrel | 1 | 1 | |||
| dexamethasone eye preparations (Ozurdex) | 2 | 2 | |||
| diphenoxylate hydrochloride with atropine sulphate | 1 | 1 | |||
| dipyridamole | 4 | 4 | |||
| dulaglutide | 1 | 1 | 1 | 3 | |
| duloxetine | 1 | 1 | |||
| dupilumab | 2 | 1 | 3 | ||
| eculizumab | 2 | 1 | 3 | ||
| elexacaftor/tezacaftor/ivacaftor | 1 | 1 | |||
| eltrombopag | 1 | 3 | 1 | 5 | |
| emicizumab | 2 | 1 | 3 | ||
| emollient (Octenisan) | 1 | 1 | |||
| empagliflozin | 5 | 5 | |||
| emtricitabine with tenofovir alafenamide | 2 | 2 | |||
| enoxaparin sodium | 4 | 2 | 6 | ||
| enteral feed (Liquid Hope) | 1 | 1 | |||
| enteral feed paediatric (Compleat) | 1 | 1 | |||
| entrectinib | 1 | 1 | |||
| eplerenone | 1 | 1 | 2 | ||
| epoetin alfa | 1 | 0 | 1 | 1 | 3 |
| erenumab | 1 | 1 | |||
| eribulin | 1 | 1 | |||
| etanercept | 2 | 1 | 1 | 4 | |
| etoricoxib | 2 | 2 | |||
| everolimus | 1 | 1 | 2 | ||
| evolocumab | 1 | 2 | 3 | ||
| fexofenadine hydrochloride | 1 | 1 | |||
| filgrastim | 1 | 1 | |||
| fish oil (PharmEPA Complete) | 1 | 1 | |||
| flunarizine | 1 | 1 | |||
| fluoxetine hydrochloride (Fluotex) | 1 | 1 | 2 | ||
| fluphenazine decanoate | 1 | 1 | |||
| fluvoxamine maleate | 1 | 1 | |||
| fostamatinib | 1 | 1 | |||
| gabapentin (Apo-Gabapentin) | 1 | 2 | 3 | ||
| ganciclovir | 1 | 1 | |||
| ganciclovir eye preparations | 3 | 1 | 4 | ||
| gemtuzumab ozogamicin | 2 | 2 | |||
| glycopyrrolate | 1 | 1 | |||
| goserelin | 1 | 1 | |||
| hydrocortisone acetate (rectal foam) (Cortifoam) | 1 | 1 | |||
| ibrutinib | 2 | 1 | 3 | ||
| icatibant | 1 | 1 | |||
| idebenone | 1 | 1 | |||
| indomethacin | 5 | 5 | |||
| infliximab | 7 | 3 | 2 | 12 | |
| insulin pump | 1 | 2 | 3 | ||
| ipilimumab | 1 | 1 | |||
| i-port (I-Port) | 1 | 1 | |||
| isoleucine | 2 | 2 | |||
| ivabradine | 3 | 3 | 6 | ||
| ketamine | 5 | 1 | 6 | ||
| ketotifen | 2 | 2 | |||
| lamotrigine | 2 | 1 | 15 | 2 | 20 |
| lanadelumab | 1 | 1 | 2 | ||
| lanreotide | 2 | 1 | 3 | ||
| lenalidomide | 4 | 3 | 7 | ||
| lenolidamide | 1 | 1 | |||
| lenvatinib | 1 | 1 | |||
| letermovir | 2 | 2 | |||
| leucine | 2 | 2 | |||
| leuprorelin acetate | 1 | 1 | |||
| levetiracetam | 2 | 1 | 3 | ||
| levocarnitine | 1 | 1 | 2 | ||
| levocetirizine | 1 | 1 | |||
| levofloxacin | 1 | 1 | 2 | ||
| lidocaine [lignocaine] | 1 | 1 | |||
| linezolid | 8 | 8 | |||
| liraglutide | 1 | 1 | |||
| luspatercept | 1 | 1 | |||
| macitentan | 2 | 2 | |||
| megestrol acetate | 1 | 1 | |||
| melatonin | 1 | 2 | 3 | ||
| mepolizumab | 3 | 3 | |||
| methylphenidate hydrochloride | 1 | 1 | 2 | ||
| metolazone | 1 | 1 | |||
| metronidazole | 1 | 1 | |||
| midostaurin | 1 | 1 | 1 | 3 | |
| migalastat | 1 | 1 | |||
| miglustat | 3 | 3 | |||
| mirabegron | 1 | 1 | |||
| mitotane | 2 | 2 | |||
| moxifloxacin | 3 | 3 | |||
| multiple sclerosis | 1 | 1 | |||
| multivitamin and mineral supplement (Clinicians Multivitamin and Mineral Boost) | 1 | 1 | |||
| mycophenolic acid | 1 | 1 | |||
| naltrexone hydrochloride | 1 | 1 | |||
| nelarabine | 1 | 1 | |||
| nimodipine | 2 | 2 | |||
| nintedanib | 1 | 1 | 2 | ||
| nirmatrelvir with ritonavir (Paxlovid) | 1 | 1 | |||
| nitazoxanide (Alinia) | 1 | 1 | |||
| nivolumab | 3 | 1 | 4 | ||
| octreotide lar | 3 | 2 | 5 | ||
| oestradiol | 2 | 2 | |||
| olanzapine (Zyprexa Zydis) | 1 | 1 | |||
| omadacycline | 1 | 1 | |||
| omeprazole (Losec) | 1 | 1 | |||
| oral feed liquid (Fortisip or Ensure Plus) | 1 | 1 | |||
| oral feed liquid fat-free (Fortijuce) | 2 | 2 | |||
| oral feed paediatric renal (Renastart) | 7 | 7 | |||
| oral supplement elemental with high medium chain triglyceride (Emsogen) | 1 | 1 | |||
| orlistat | 1 | 1 | |||
| oseltamivir | 1 | 1 | |||
| oxandrolone | 1 | 1 | |||
| oxcarbazepine | 1 | 1 | |||
| oxybutynin | 1 | 1 | |||
| palbociclib | 1 | 1 | |||
| paliperidone | 4 | 4 | |||
| paliperidone depot injection (Invega Trinza) | 1 | 1 | |||
| palivizumab | 1 | 3 | 2 | 6 | |
| paracetamol | 1 | 1 | |||
| paraldehyde | 1 | 1 | |||
| parecoxib | 1 | 1 | |||
| paromomycin | 3 | 3 | |||
| paroxetine (Aropax) | 1 | 1 | |||
| pazopanib | 3 | 1 | 1 | 5 | |
| pegylated interferon alfa-2a | 4 | 0 | 1 | 0 | 5 |
| pegylated liposomal doxorubicin hydrochloride | 1 | 3 | 4 | ||
| pembrolizimab | 6 | 10 | 16 | ||
| perampanel | 4 | 4 | |||
| pertuzumab | 1 | 1 | 2 | ||
| phenelzine sulphate | 1 | 1 | |||
| pimecrolimus | 1 | 1 | |||
| pirfenidone | 1 | 1 | |||
| plerixafor | 1 | 1 | |||
| polatuzumab vedotin | 1 | 1 | |||
| ponatinib | 3 | 1 | 4 | ||
| posaconazole | 8 | 1 | 9 | ||
| potassium chloride | 1 | 1 | |||
| potassium citrate | 2 | 2 | |||
| prednisolone sodium phosphate (Redipred) | 1 | 1 | |||
| pristinamycin | 9 | 9 | |||
| probiotics | 1 | 1 | |||
| prucalopride | 2 | 2 | 1 | 5 | |
| quinacrine [mepacrine] | 1 | 2 | 3 | ||
| quinidine | 1 | 1 | |||
| rasburicase | 1 | 1 | |||
| retinol | 1 | 1 | |||
| ribavirin | 1 | 2 | 3 | ||
| rifaximin | 1 | 1 | |||
| riluzole | 1 | 1 | |||
| risankizumab | 1 | 1 | |||
| risdiplam | 1 | 1 | |||
| rituximab | 38 | 0 | 7 | 5 | 50 |
| rivastigmine | 1 | 1 | |||
| romiplostim | 2 | 2 | |||
| rosuvastatin | 1 | 1 | |||
| rufinamide | 11 | 11 | |||
| ruxolitinib | 3 | 2 | 5 | ||
| sapropterin dihydrochloride | 1 | 1 | |||
| secukinumab | 3 | 1 | 2 | 6 | |
| selegiline hydrochloride | 1 | 1 | |||
| selexipag | 2 | 2 | |||
| selumetinib | 1 | 1 | |||
| sildenafil | 1 | 1 | |||
| sirolimus | 2 | 2 | 4 | ||
| sirolimus ointment | 6 | 6 | |||
| sitafloxacin | 1 | 1 | |||
| sodium benzoate | 1 | 1 | |||
| sodium chloride | 4 | 1 | 5 | ||
| sodium phenylbutyrate | 1 | 1 | |||
| sofosbuvir with velpatasvir (Epclusa) | 2 | 2 | |||
| somatropin | 1 | 1 | |||
| spiramycin | 1 | 1 | |||
| stanozolol | 4 | 4 | |||
| sulthiame | 1 | 1 | |||
| sunitinib | 1 | 1 | |||
| tacrolimus | 4 | 4 | |||
| tacrolimus ointment | 1 | 1 | |||
| tacrolimus suppositories | 1 | 1 | |||
| tadalafil | 3 | 1 | 4 | ||
| tafamidis | 1 | 1 | |||
| taurolidine and citrate | 2 | 2 | |||
| teduglutide | 1 | 1 | 2 | ||
| temozolomide | 2 | 2 | |||
| tenofovir alafenamide | 1 | 1 | |||
| terazosin | 1 | 1 | |||
| terbutaline | 1 | 1 | |||
| teriparatide | 1 | 3 | 4 | ||
| tetracycline | 1 | 1 | |||
| thalidomide | 3 | 3 | |||
| ticagrelor | 3 | 3 | |||
| tinidazole | 5 | 5 | |||
| tirofiban | 1 | 1 | |||
| tizanidine | 1 | 1 | |||
| tobramycin | 2 | 1 | 3 | ||
| tocilizumab | 48 | 3 | 4 | 55 | |
| tofacitinib | 1 | 2 | 1 | 4 | |
| topotecan | 1 | 1 | |||
| trametinib | 1 | 3 | 4 | ||
| trastuzumab subcutaneous | 1 | 1 | |||
| trientine hydrochloride | 1 | 1 | |||
| triiodothyroacetic acid | 1 | 1 | |||
| tyrosine | 2 | 2 | |||
| upadacitinib | 2 | 2 | |||
| uridine | 2 | 2 | |||
| ursodeoxycholic acid | 1 | 1 | |||
| ustekinumab | 3 | 8 | 2 | 13 | |
| valganciclovir | 8 | 8 | |||
| vancomycin | 1 | 1 | |||
| varicella zoster virus (oka strain) live attenuated vaccine [shingles vaccine] (Zostavax) | 1 | 1 | |||
| vedolizumab | 1 | 3 | 1 | 5 | |
| vemurafenib | 1 | 1 | |||
| venetoclax | 2 | 3 | 5 | ||
| venlafaxine (Efexor-XR) | 1 | 1 | |||
| vinorelbine | 1 | 1 | |||
| vitamin a - retinol | 1 | 1 | |||
| voriconazole | 7 | 7 | |||
| whole thyroid extract | 1 | 1 | |||
| zonisamide | 11 | 1 | 12 | ||
| Grand Total | 504 | 4 | 284 | 95 | 887 |