Klean Prep: Discontinuation

Last Updated: 26 April 2023

Klean Prep has been discontinued globally (Pharmacode 790753). We listed a replacement Plenvu (Pharmacode 2569671) on 1 May 2023.

Affected product

Norgine (the supplier) discontinued Klean Prep (macrogol 3350 + potassium chloride, sodium chloride, sodium sulfate) – Pharmacode: 790753. This is a global issue.

We anticipate supplies of Klean Prep ran out during August 2023. Klean Prep remained listed until 1 April 2024 to allow time for all stock to be used and claimed for.

Hospital Medicine List (HML) listing for Klean Prep(external link)

This does not affect other bowel-cleansing preparations listed in the HML(external link)

Note: Klean Prep was only listed on the HML.

Alternative product

We listed Plenvu (Pharmacode: 2569671) from 1 May 2023 as an alternative. We secured Plenvu through our annual tender process. This listing provides continuity of supply for people where the other funded options may not be suitable.

HML listing for Plenvu(external link)

Full decision details for the Plenvu listing

Key dates

1 May 2023 – Plenvu listed on the Pharmaceutical Schedule.

August 2023 – Stock of Klean Prep is expected to run out.

1 April 2024 – Klean Prep will be delisted from the Pharmaceutical Schedule.

Key differences between Klean Prep and Plenvu

There are some differences between Klean Prep and Plenvu. These are summarised in the table below. Full details about Plenvu and Klean Prep are available from the Medsafe datasheet.

Product name	Plenvu	Klean Prep
Ingredients	Macrogol 3350 + sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate and ascorbic acid	Macrogol 3350 with potassium chloride, sodium bicarbonate, sodium chloride, and sodium sulfate
Medsafe Datasheet	Plenvu Datasheet(external link)	Klean-Prep Datasheet(external link)
Form	Powder for oral solution, 3 sachets	Powder for oral solution, 4 sachets
Active ingredients details	Dose 1 sachet: macrogol 3350 100 g potassium chloride 1 g sodium chloride 2 g sodium sulfate 9 g Dose 2 (sachet A and B) Sachet 2A: macrogol 3350 40 g potassium chloride 1.2 g sodium chloride 3.2 g Sachet 2B: ascorbic acid 7.54 g sodium ascorbate 48.11 g	4x sachets each containing: macrogol 3350 59 g potassium chloride 0.7425 g sodium bicarbonate 1.685 g sodium chloride 1.465 g sodium sulfate 5.685 g
Preparation instructions	The first dose is supplied in sachet 1. Dose 2 is supplied in two sachets, sachet A and sachet B. Each dose is made up by dissolving the sachet(s) with 500 mL of water. An additional 500 mL of clear fluid must be taken with each dose. Each 500 mL dose and 500 mL additional clear fluids should be taken over 60 minutes.	Each sachet is dissolved in 1 L of water. Usual dose is 4 sachets taken at a rate of 250 mL every 10 to 15 minutes.
Recommended dosing regimen	Two-day split dosing schedule with the first 500 mL dose of PLENVU (including additional 500 mL of clear fluid) taken in the evening before the clinical procedure and the second 500 mL dose (including an additional 500 mL of clear fluid) in the morning of the day of the clinical procedure (approximately 12 hours after the start of the first dose) Morning only dosing schedule with both doses taken in the morning of the day of the clinical procedure (including an additional 500 mL of clear fluid); the second dose should be taken a minimum of 2 hours after the start of the first dose Day before dosing schedule with both doses taken in the evening before the clinical procedure (including an additional 500 mL of clear fluid); the second dose should be taken a minimum of 2 hours after the start of the first dose.	All four sachets should be taken within 4-6 hours, or Administration may be divided, for example, taking 2 sachets during the evening before the examination, and the remaining 2 sachets on the morning of the examination.
Flavour	Mango and fruit punch	Vanilla
Excipients	Citric acid, mango flavour VA93382, sucralose, aspartame, fruit mix flavour (fruit punch) FV654 VA93402	Aspartame, vanilla
Reconstituted shelf life	24 hours reconstituted stored at or below 25^oC (or in a refrigerator).	24 hours reconstituted stored in the refrigerator (2-8 degrees).

Who to contact

If you have any queries regarding the funding of bowel cleansing preparations, email enquiry@pharmac.govt.nz