Adefovir dipivoxil (Hepsera): Discontinuation

Gilead Sciences (NZ) have stopped making adefovir dipivoxil (Hepsera).

About this discontinuation

Adefovir dipivoxil was an antiviral medicine used to treat Hepatitis B. There were fewer than 40 people in New Zealand taking this medicine.

Supplies of adefovir dipivoxil ran out in 2020. 

We know that changing medicines can be disruptive. We apologise for any inconvenience.

Information for people taking adefovir dipivoxil

You will need to talk to your prescriber about an alternative to adefovir dipivoxil. There are other funded alternatives to treat hepatitis B. Your health care professional knows you and your clinical circumstances best. They are in the best place to advise you on the options.

Information for prescribers

Any of your patients taking adefovir dipivoxil will need to change to a different antiviral treatment by 1 November 2020.

Prescribers will need to:

  • ensure no new patients are started on adefovir dipivoxil
  • transition patients currently on adefovir dipivoxil to alternative treatments as soon as possible.

There are other alternative currently funded treatments available to treat Hepatitis B.

Information for pharmacists

Please advise patients taking adefovir dipivoxil to see their prescriber so that they can change to a different Hepatitis B treatment as soon as possible.

We have advised prescribers to transition their patients to an alternative treatment.

Key dates:

  • Late 2020: Stock of adefovir dipivoxil runs out
  • 28 February 2021: Existing stock of adefovir dipivoxil expires
  • 1 March 2021: Adefovir dipivoxil will be delisted 1 March from 2021

Who to contact

If you have any questions about this discontinuation, email