Cilazapril: Brand change and Discontinuation

Brand change Discontinuation Active

PHARMAC is aware of only one manufacturer of the active ingredient in cilazapril internationally. Cilazapril is used infrequently or not at all in other countries.

This means if a supply issue were to occur, then it would likely be difficult to resolve or mitigate. This could have a significant impact on patients and health care professionals.

The supply chain challenges presented by the COVID-19 pandemic have once again shone a light on New Zealand’s over-reliance on cilazapril. 

What prescribers can do

When prescribing an ACE inhibitor, consider prescribing a different one than cilazapril.

BPAC has prepared advice comparing the funded ACE inhibitors, including recommended doses. 

The future 

PHARMAC has secured supplies of a new brand of cilazapril tablets (Zapril) until 2022. We cannot guarantee supplies after 2022.  

Supply of cilazapril with hydrochlorothiazide has been discontinued and supplies are expected to run out by the end of 2020.