Request for proposals - influenza vaccine

Medicines

RFP Closed

PHARMAC invites proposals for the supply of seasonal influenza vaccine in New Zealand.

This request for proposals (RFP) letter incorporates the following schedules:

  • Schedule 1 specifies the pharmaceuticalfor which PHARMAC is requesting proposals and sets out the background to the RFP and the types of proposals sought;
  • Schedule 2 describes the process that PHARMAC expects to follow in relation to the RFP;
  • Schedule 3 sets out information about the estimated size of the current subsidised market for the pharmaceutical; and
  • Schedule 4 contains the RFP form in which you are to provide details of your proposal.

If you wish to submit a proposal, you must submit it via the Government Electronic Tenders Service (GETS) no later than 5:00pm on 3 March 2016.

If you have any questions about this RFP, please email Chris Chapman or Caroline de Luca.

Schedule 1: Pharmaceutical, background to RFP and types of proposals sought

Pharmaceutical

PHARMAC is interested in considering any proposal from suppliers of seasonal influenza vaccine for supply to the eligible population for the annual national influenza vaccination campaign in New Zealand. Exact start and end dates for each campaign’s season will be notified each year.

Proposals should be in relation to the supply of influenza vaccine alone and should not include any other vaccines or pharmaceuticals either related or not to influenza vaccination.

Background to RFP

Eligibility criteria

Since 1997 the New Zealand Government has subsidised influenza vaccine for eligible members of the population meeting set criteria.

The current eligibility criteria in Section I (community access) of the Pharmaceutical Schedule are set out below. The eligibility criteria may be subject to change before or during the term of any agreement that may result from this RFP:

INFLUENZA VACCINE – [Xpharm]

A) is available each year for patients who meet the following criteria, as set by PHARMAC:

a) all people 65 years of age and over; or
b) people under 65 years of age who:

i) have any of the following cardiovascular diseases:

a) ischaemic heart disease, or
b) congestive heart failure, or
c) rheumatic heart disease, or
d) congenital heart disease, or
e) cerebo-vascular disease; or

ii) have either of the following chronic respiratory diseases:

a) asthma, if on a regular preventative therapy, or
b) other chronic respiratory disease with impaired lung function; or

iii) have diabetes; or
iv) have chronic renal disease; or
v) have any cancer, excluding basal and squamous skin cancers if not invasive; or
vi) have any of the following other conditions:

a) autoimmune disease, or
b) immune suppression or immune deficiency, or
c) HIV, or
d) transplant recipients, or
e) neuromuscular and CNS diseases/disorders, or
f) haemoglobinopathies, or
g) are children on long term aspirin, or
h) have a cochlear implant, or
i) errors of metabolism at risk of major metabolic decompensation, or
j) pre and post splenectomy, or
k) down syndrome, or

vii) are pregnant; or

c) children aged four years and under who have been hospitalised for respiratory illness or have a history of significant respiratory illness;

Unless meeting the criteria set out above, the following conditions are excluded from funding:

a) asthma not requiring regular preventative therapy,
b) hypertension and/or dyslipidaemia without evidence of end-organ disease.

B) Doctors are the only Contractors entitled to claim payment from the Funder for the supply of influenza vaccine to patients eligible under the above criteria for subsidised immunisation and they may only do so in respect of the influenza vaccine listed in the Pharmaceutical Schedule.

C) Individual DHBs may fund patients over and above the above criteria. The claiming process for these additional patients should be determined between the DHB and Contractor.

D) Stock of the seasonal influenza vaccine is typically available from February until late July with suppliers being required to ensure supply until at least 30 June. Exact start and end dates for each season will be notified each year.

Eligibility criteria in hospitals are the same as for Section I with the addition of patients who are compulsorily detained long-term in a forensic unit within a DHB hospital” and removal of clauses B-D.

PHARMAC currently subsidises/lists two influenza vaccines for eligible patients as follows:

   

Subsidy/Price

Per

Fully Subsidised

Brand or Generic Manufacturer

INFLUENZA VACCINE –[Xpharm]

         

Inj 45 mcg in 0.5 ml syringe

………………….

90.00*

10

P

Fluarix

         

Influvac

* both currently listed brands are subject to a confidential rebate arrangement.

Under current arrangements 250,000 doses of Fluarix are distributed each season in preference to Influvac, after which supplies of Influvac would be expected to meet the remaining demand of the market.

Distribution

It is our preference that supplier(s) continue to manage distribution under any proposals received as a result of this RFP. Proposals should therefore include distribution to vaccinators within the price of the vaccine.

Proposals should contain information on the nominated distributor’s capabilities in managing the seasonal influenza vaccine campaign including delivery timeframes, returns policy and any minimum order requirements.

The resulting contract(s) with the supplier(s) would require the distributor to comply with the most recent New Zealand Immunisation Advisory Centre (IMAC) Vaccine Storage and Distribution National Standards (available from http://www.immune.org.nz/health-professionals/cold-chain(external link)) and with any changes to these standards that might occur during the tenure of a supply agreement.

Stock should be available to order by 15 March each year. Suppliers should be aware of the high demand for the vaccine in the early stages of each season. Data shows that each year about half of all vaccines ordered are ordered within the first month of the season, and suppliers should be prepared for this busier period. Supply and payment conditions will be included in any supply agreement as a result of this RFP to take into account the importance of delivery timeframes.

PHARMAC is aware that DHBs are investigating allowing pharmacists to claim for administration of funded vaccines. It is likely that this may occur prior to 2020 and so be relevant to this RFP. Suppliers should be aware of this possible change and consider its effect on uptake and on distribution costs.

Reporting

The supplier(s) would be required to provide comprehensive reports to PHARMAC throughout the influenza season including details of sales broken down by District Health Board (DHB) area, not just the total sales for the country. The reports would be required to be supplied to PHARMAC on a monthly basis in an electronic Excel spreadsheet format with sales volumes reported on a per week basis.

Contract duration

The resulting contract(s) from this RFP process would be for a period of three seasonal influenza vaccine campaign years until the end of the 2019 season. During this period the eligibility criteria may change and any contract(s) resulting from this process would provide for this.

Claiming

Currently, the vaccinator pays for the cost of the influenza vaccine to the distributor and is reimbursed through claims made to the DHBs’ payment agent, Sector Services for the cost of the vaccine and the immunisation service. It is proposed that this claiming mechanism would remain unchanged.

Private (patient funded) vaccinations

For those patients that do not meet the eligibility criteria, seasonal influenza vaccination is available at a cost to the patient through the private market. In some cases these are funded by an employer.

There is no requirement for the private market seasonal influenza vaccine to be purchased from the same supplier as the subsidised seasonal influenza vaccine

However, for simplicity, PHARMAC is aware that many vaccinators only stock the subsidised brands and therefore the subsidised brands supply a large proportion of the private market as well. Suppliers would need to consider the impact this may have on the volumes of vaccines required. They are expected to ensure that private market demand does not affect their ability to supply the subsidised market.

Promotion

The Immunisation Advisory Centre (IMAC) coordinates annual promotional resources, including the Influenza Kit. It is anticipated that supplier(s) would provide information and work with NISG when requested. Further information about NISG can be found at www.influenza.org.nz(external link).

Pandemic Supply

Any contract(s) resulting from this process would include provisions allowing exclusivity to be suspended in the event of an influenza pandemic. The provisions would reflect compliance with any Ministry of Health and WHO requirements with regard to pandemic supply situations.

Types of proposals sought

Suppliers must submit two proposals as follows, being one for each of the following:

  • subsidised supply for a maximum period of three winter seasonal influenza vaccine campaigns until the end of 2019 season, where the supplier meets the demand for doses of seasonal influenza vaccine (“Routine Supplier”), other than up to 250,000 initial doses which would be supplied by an alternative supplier; and
  • a proposal to be the supplier of a fixed volume of an initial 250,000 doses that are to be supplied by 15 March of the relevant influenza season, which will occur prior to the supply of the seasonal influenza vaccine by the Routine Supplier.

Suppliers may in addition to the above two proposals exercise an option to submit a proposal in relation to a sole subsidised supply arrangement for:

  • sole subsidised supply for a maximum period of three winter seasonal influenza vaccine campaigns until the end of 2019 season, where the supplier meets the demand for all funded doses of seasonal influenza vaccine.

Suppliers may also exercise an option to submit other types of proposals, including but not limited to:

  • supply of a fixed volume of doses per season. Note, it is possible agreement(s) would be necessary with other suppliers to ensure sufficient stock was supplied to cover the entire market and therefore if a proposal of this type is submitted there could be no restriction on any other supplier also being subsidised.
  • listed subsidised supply at a secured price for a period to be specified in the proposal. Note this type of proposal could not involve any restriction on any other supplier also being subsidised.

PHARMAC is aware that, under a multiple supplier arrangement, it is possible PHARMAC would be required to have some co-ordination role in the distribution of the seasonal influenza vaccines; this would be negotiated with the applicable suppliers if necessary. However, please note that PHARMAC does not intend to contract with a distributor itself or to manage any payments for distribution services.

Within any of the above proposals, suppliers may wish to offer to supply:

  • Trivalent vaccines
  • Quadrivalent vaccines
  • An arrangement whereby trivalent vaccines are supplied for the first one or two seasonal campaigns, followed by the supply of quadrivalent vaccines.

Suppliers must submit proposals which do not include any change to the current Pharmaceutical Schedule list price of influenza vaccines ($9.00 per unit) for trivalent influenza vaccines. However, proposals for quadrivalent vaccines with a different list price may be submitted.

The distributor must provide a free phone, free fax and online ordering system that vaccinators could use to place orders. The ordering system would need to be in place by 1 January 2017 to allow vaccinators to order influenza vaccine prior to the influenza season.

PHARMAC is not willing to consider the following types of proposals:

  • Proposals involving products other than the influenza vaccine;
  • Proposals involving changes to the eligibility restrictions;
  • Expenditure risk sharing mechanisms based on claims data or that would require any audit of claims data;
  • Proposals relating to pandemic supply – the Ministry of Health recently ran its own procurement process for pandemic vaccine and this RFP is unconnected to that process; and
  • Proposals where the supplier would not pay for distribution costs.

Schedule 2: RFP process

PHARMAC expects to follow the process set out below in the sequence indicated.

Submission

  1. You may submit more than one proposal. Each proposal will be considered as a separate proposal.
  2. Proposals must be submitted no later than 5:00pm New Zealand time) on 3 March 2016. Late proposals will only be considered at PHARMAC’s discretion, taking into account the need for fairness to other suppliers and integrity of the RFP process.
  3. If you have any inquiries about this RFP you should submit them on GETS or alternatively email Chris Chapman or Caroline de Luca. 
  4. You cannot withdraw your proposal, once submitted, while the RFP process is continuing.
  5. All proposals must be submitted to PHARMAC via the GETS website to the attention of Christine Chapman, Senior Therapeutic Group Manager.

Evaluation

Negotiation

  1. PHARMAC may negotiate with the submitter(s) of one or more preferred proposals, in the latter case whether or not the acceptance of either supplier’s proposal would exclude acceptance of the other proposal.
  2. Negotiations will proceed on the basis that PHARMAC’s standard terms and conditions for supply of pharmaceuticals, which are available on request from PHARMAC, will apply. In addition, a number of terms and conditions specific to the supply of influenza vaccine will be necessary. As an indication, some of these are outlined in Schedule 1 above, but this is without limitation to other clauses which may be necessary.
  3. Given that PHARMAC expects your proposal to be the best you can offer, PHARMAC does not intend to initiate negotiation with you on price. However, PHARMAC does not exclude the possibility that the final price agreed will be different from the price put forward in your proposal, as a result of the impact that other negotiated terms may have on price.
  4. PHARMAC may negotiate and enter into a provisional agreement with a preferred supplier(s) on whatever special terms, in addition to PHARMAC’s standard terms and conditions, PHARMAC considers appropriate.
  5. If PHARMAC and the supplier(s) are unable to reach a provisional agreement within what PHARMAC considers to be a reasonable time, PHARMAC may terminate those negotiations and negotiate with a different supplier(s).

Consultation and approval

Miscellaneous

PHARMAC may consult with you before deciding whether to disclose Confidential Information for the purposes described in sub-clauses (i) to (iv) above. You acknowledge, however, that it is for PHARMAC to decide, in its absolute discretion, whether it is necessary or appropriate to disclose information for any of the above purposes, provided that PHARMAC shall act in good faith in disclosing any Confidential Information.

Anticipated timetable

Schedule 3: Current listing and market information

The following information relates to the estimated subsidised market size for seasonal influenza vaccine. The information is approximate and indicative only. PHARMAC makes no representation as to the accuracy of this information or as to the level of sales or likely sales of seasonal influenza vaccine and, while PHARMAC has taken all reasonable care in preparing the information set out below, it accepts no liability for any errors or omissions in the information. PHARMAC is not obliged to notify you in the event of any change to the figures below.

Year

Total vaccines distributed (private and funded)

Total vaccines subsidised in the community

2011

990,000

596,000

2012

1,000,000

612,000

2013

1,250,000

718,000

2014

1,210,000

687,000

2015

1,210,000

707,000

The total vaccine use each season is influenced by the Ministry of Health targets. Currently it aims to have 1.2million vaccines distributed each year (private and funded). The Ministry could alter this target in the future.

In a typical season, half of all vaccines are ordered within the first month. After approximately two months, we typically see demand becoming much flatter, and orders in the latter half of the season are much lower. Demand patterns are also affected by weekends and holidays such as Easter.

Influenza doses graph

Schedule 4: Proposal form

An electronic version of this form is available on GETS (www.gets.govt.nz(external link)). You should expand the boxes as necessary.

We have also linked a Word document [DOCX, 25 KB].